NDLI: Cortical mapping of the optically evoked responses in channelrhodopsin-2 mouse model

Content Provider	IEEE Xplore Digital Library
Author	Guk Bae Kim Cho, J.R. Hee-Sup Shin Jee Hyun Choi
Copyright Year	2011
Description	Author affiliation: Brain Science Institute of the Korea Institute of Science and Technology (KIST), Seoul, 136-791, South Korea (Guk Bae Kim) \|\| Department of Neurology, Samsung Medical Center, Seoul, 135-710, South Korea (Cho, J.R.) \|\| Brain Science Institute of KIST, Seoul and Department of Neuroscience, University of Science and Technology (UST), Daejeon, South Korea (Hee-Sup Shin) \|\| Brain Science Institute of KIST, Seoul and Department of Neuroscience, UST, Daejeon, South Korea (Jee Hyun Choi)
Abstract	Little is known about the information transfer properties of large-scale neural circuit in brain system. We applied optical deep brain stimulation to define the properties of information flow within a living brain assisted by channel rhodopsin-2 (ChR2) transgenic mice, of which neurons express the light-activated ion channel. We first characterized the responses of neuronal ensemble to the impinged light with respect to stimulation parameters by co-registering local field potentials with optical stimulation. Secondly, we applied recently developed polyimide based microarray for mouse electroencephalogram (EEG) to obtain the cortical responses with respect to deep brain stimulation. Particularly, the spatiotemporal cortical mapping with respect to deep brain stimulation of primary somatosensory cortex and hippocampus CA1 were presented in this article.
Starting Page	6769
Ending Page	6772
File Size	1874899
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6091669
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Stimulated emission Optical pulses Mice Optical fibers Electroencephalography Biomedical optical imaging
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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