NDLI: Using point process models to describe rhythmic spiking in the subthalamic nucleus of Parkinson's patients

Content Provider	IEEE Xplore Digital Library
Author	Eden, Uri T. Amirnovin, Ramin Eskandar, Emad N.
Copyright Year	2011
Description	Author affiliation: Department of Mathematics and Statistics, Boston University, Boston, MA 02215 USA (Eden, Uri T.) \|\| Al-Rohdan Laboratories - MGH-HMS Center for Nervous System Repair, Department of Neurosurgery, Massachusettes General Hospital, Boston, MA 02114 (Amirnovin, Ramin; Eskandar, Emad N)
Abstract	Neurological disease is often associated with changes in firing activity in specific brain areas. Accurate statistical models of neural spiking can provide insight into the mechanisms by which the disease develops and clinical symptoms manifest. Point process theory provides a powerful framework for constructing, fitting, and evaluating the quality of neural spiking models. We illustrate an application of point process modeling to the problem of characterizing abnormal oscillatory firing patterns of neurons in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD). We characterize the firing properties of these neurons by constructing conditional intensity models using spline basis functions that relate the spiking of each neuron to movement variables and the neuron's past firing history, both at short and long time scales. By calculating maximum likelihood estimators for all of the parameters and their significance levels, we are able to describe the relative propensity of aberrant STN spiking in terms of factors associated with voluntary movements, with intrinsic properties of the neurons, and factors that may be related to dysregulated network dynamics.
Starting Page	757
Ending Page	760
File Size	629240
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6090173
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Firing Neurons History Spline Parkinson's disease Data models
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Using point process models to describe rhythmic spiking in the subthalamic nucleus of Parkinson's patients

Point process modeling reveals anatomical non-uniform distribution across the Subthalamic Nucleus in Parkinson's disease

Point Process Modeling Reveals Anatomical Non-Uniform Distribution across the Subthalamic Nucleus in Parkinson’s Disease

Characteristics of the neuronal firing patterns in the subthalamic nucleus with graded dopaminergic cell loss in the nigrostriatal pathway

An information transmission measure for the analysis of effective connectivity among cortical neurons

Neuronal pathways involved in deep brain stimulation of the subthalamic nucleus for treatment of parkinson’s disease

Using Point Process Models to Compare Neural Spiking Activity in the Subthalamic Nucleus of Parkinson's Patients and a Healthy Primate

Quantifying drug induced dyskinesia in Parkinson's disease patients using standardized videos

Muscle artifacts in single trial EEG data distinguish patients with Parkinson's disease from healthy individuals

Using point process models to describe rhythmic spiking in the subthalamic nucleus of Parkinson's patients

Similar Documents

Using point process models to describe rhythmic spiking in the subthalamic nucleus of Parkinson's patients

Point process modeling reveals anatomical non-uniform distribution across the Subthalamic Nucleus in Parkinson's disease

Point Process Modeling Reveals Anatomical Non-Uniform Distribution across the Subthalamic Nucleus in Parkinson’s Disease

Characteristics of the neuronal firing patterns in the subthalamic nucleus with graded dopaminergic cell loss in the nigrostriatal pathway

An information transmission measure for the analysis of effective connectivity among cortical neurons

Neuronal pathways involved in deep brain stimulation of the subthalamic nucleus for treatment of parkinson’s disease

Using Point Process Models to Compare Neural Spiking Activity in the Subthalamic Nucleus of Parkinson's Patients and a Healthy Primate

Quantifying drug induced dyskinesia in Parkinson's disease patients using standardized videos

Muscle artifacts in single trial EEG data distinguish patients with Parkinson's disease from healthy individuals

Using point process models to describe rhythmic spiking in the subthalamic nucleus of Parkinson's patients