NDLI: Aberrant auditory evoked responses in schizophrenia: Evidence from single-trial analysis

Content Provider	IEEE Xplore Digital Library
Author	Iyer, D. Boutros, N.N. Zouridakis, G.
Copyright Year	2011
Description	Author affiliation: Department of Electrical and Computer Engineering, University of Houston, Houston, TX 77204 USA (Iyer, D.) \|\| Department of Psychiatry and Behavioral Neuro-sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA (Boutros, N.N.) \|\| Departments of Engineering Technology, Computer Science, and Electrical and Computer Engineering, University of Houston, Houston, TX 77204-3058 USA (Zouridakis, G.)
Abstract	The average N100 (a negative response occurring around 100 ms poststimulus) component of the auditory evoked potential (EP) has been recently used in the study of schizophrenia. Averaging, however, eliminates all temporal variability of the recorded signals and, therefore, hampers the exploration of the temporal dynamics underlying the generation of the N100 component. In this study, we analyzed EPs on a single-trial basis using an iterative independent component analysis procedure that is capable of extracting individual components out of an entire EP waveform. This approach allowed estimation of an N100 in each single trial and measurement of its morphological features such as polarity, which could be either negative (most frequently) or positive (less frequently). In the latter case, the N100 component was termed aberrant. We analyzed responses from 23 normal controls (NC) and 15 schizophrenia (SZ) patients in a paired stimulus paradigm, where a first stimulus S1 was followed by a second one S2 0.5 s later. To compare N100 responses within and across the two subject groups, we defined a negative polarity index NPI as the percentage of single trials that had a negative polarity N100. Our results show significantly higher NPI values in NC compared to SZ, for both the S1 and S2 responses. Additionally, the difference in NPI values between the S1 and S2 responses was significant in NC but not in SZ. We conclude that both normal and schizophrenia subjects exhibit aberrant N100 responses, but these events are more frequent in the SZ patient group. The higher number of aberrant responses can explain the lower amplitude EPs typically observed in schizophrenia, and may be one of the factors contributing to sensory gating deficits consistently reported in these patients.
Starting Page	4406
Ending Page	4409
File Size	516166
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6091093
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Estimation USA Councils Electroencephalography Psychiatry Independent component analysis Educational institutions Electric potential
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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