NDLI: Towards building computerized image analysis framework for nucleus discrimination in microscopy images of diffuse glioma

Content Provider	IEEE Xplore Digital Library
Author	Jun Kong Cooper, L. Kurc, T. Brat, D. Saltz, J.
Copyright Year	2011
Description	Author affiliation: Emory University, Center for Comprehensive Informatics, Atlanta, GA 30322 (Jun Kong; Cooper, L.; Kurc, T.; Saltz, J.) \|\| Emory University, Dept. of Pathology and Lab Medicine, Atlanta, GA 30322 (Brat, D.)
Abstract	As an effort to build an automated and objective system for pathologic image analysis, we present, in this paper, a computerized image processing method for identifying nuclei, a basic biological unit of diagnostic utility, in microscopy images of glioma tissue samples. The complete analysis includes multiple processing steps, involving mode detection with color and spatial information for pixel clustering, background normalization leveraging morphological operations, boundary refinement with deformable models, and clumped nuclei separation using watershed. In aggregate, our validation dataset includes 220 nuclei from 11 distinct tissue regions selected at random by an experienced neuropathologist. Computerized nuclei detection results are in good concordance with human markups by both visual appraisement and quantitative measures. We compare the performance of the proposed analysis algorithm with that of CellProfiler, a classical analysis software for cell image process, and present the superiority of our method to CellProfiler.
Starting Page	6605
Ending Page	6608
File Size	1228547
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6091629
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Image color analysis Microscopy Image segmentation Humans Image reconstruction Image analysis Kernel
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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