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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Pungkham, H. Swatdipakdi, N. Theerasilp, M. Karnkla, S. Chittchang, M. Ploypradith, P. Nasongkla, N. |
| Copyright Year | 2011 |
| Description | Author affiliation: Chulabhorn Research Institute and Chulabhorn Graduate Institute, Bangkok 10210, Thailand (Chittchang, M.; Ploypradith, P.) || Biomedical Engineering Department, Mahidol University, Nakorn Pathom CO 73170, Thailand (Nasongkla, N.) || Biomedical Engineering Department, Mahidol University, Nakorn Pathom 73170, Thailand (Pungkham, H.; Swatdipakdi, N.; Theerasilp, M.; Karnkla, S.) |
| Abstract | Lamellarin N (Lam N) is a member of an interesting marine natural product class isolated from mollusks and subsequently found in ascidians and sponges. The limited aqueous solubility of Lam N hinders further studies on its cytotoxic activity against cancer cells. In this study, micelles comprising poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) and poly(ethylene glycol)-block-poly(D, L-lactide) (PEG-b-PLA) were developed to circumvent Lam N limited aqueous solubility. The results showed that an increase in the molecular weight of both core materials resulted in higher Lam N loading content, whereas the release of Lam N decreased as a function of molecular weight of PCL and PLA. With less hydrophobic property, PLA micelles provided faster Lam N release. Thus, polymeric micelles could be utilized as controlled-release delivery systems for poorly water soluble Lam N. |
| Starting Page | 3245 |
| Ending Page | 3248 |
| File Size | 361431 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424441211 |
| ISSN | 1557170X |
| e-ISBN | 9781457715891 |
| e-ISBN | 9781424441228 |
| DOI | 10.1109/IEMBS.2011.6090882 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-08-30 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Programmable logic arrays Loading Polymers Drugs Solvents Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition |
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