NDLI: Continuous arterial spin labeling of mouse cerebral blood flow using an actively-detuned two-coil system at 9.4T

Content Provider	IEEE Xplore Digital Library
Author	Hongxia Lei Pilloud, Y. Magill, A.W. Gruetter, R.
Copyright Year	2011
Description	Author affiliation: Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, EPFL-SB-IPSB-LIFMET, CH F1 627, Station 6, Lausanne, CH1015, Switzerland (Hongxia Lei) \|\| Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland (Pilloud, Y.; Gruetter, R.) \|\| Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; Department of Radiology, University of Lausanne, Lausanne, Switzerland (Magill, A.W.)
Abstract	Among numerous magnetic resonance imaging (MRI) techniques, perfusion MRI provides insight into the passage of blood through the brain's vascular network non-invasively. Studying disease models and transgenic mice would intrinsically help understanding the underlying brain functions, cerebrovascular disease and brain disorders. This study evaluates the feasibility of performing continuous arterial spin labeling (CASL) on all cranial arteries for mapping murine cerebral blood flow at 9.4T. We showed that with an active-detuned two-coil system, a labeling efficiency of 0.82±0.03 was achieved with minimal magnetization transfer residuals in brain. The resulting cerebral blood flow of healthy mouse was 99±26mL/100g/min, in excellent agreement with other techniques. In conclusion, high magnetic fields deliver high sensitivity and allowing not only CASL but also other MR techniques, i.e. $^{1}H$ MRS and diffusion MRI etc, in studying murine brains.
Starting Page	6993
Ending Page	6996
File Size	770833
Page Count	4
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6091768
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mice Labeling Coils Blood flow Magnetic resonance imaging In vivo
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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