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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Y. L. Lv, H. Y. Zhang, Q. |
| Description | Country affiliation: China Author Affiliation: Wang YL ( Department of Pharmacy, The First Affiliated Hospital, Shantou University Medical College, Shantou, China.); Lv HY ( Department of Pharmacy, The First Affiliated Hospital, Shantou University Medical College, Shantou, China.); Zhang Q ( Department of Pharmacy, The First Affiliated Hospital, Shantou University Medical College, Shantou, China.) |
| Abstract | We investigated the effect of flavonoid compounds extracted from species of genus Iris L. on carbon tetrachloride (CCl4)-induced rat liver fibrosis. Thirty Sprague-Dawley rats were randomly divided into normal control group, liver fibrosis model group, and drug treatment group (N = 10 each). Next, 0.2 mL/100 g CCl4 was subcutaneously injected for 6 weeks in both model and treatment rats to generate the liver fibrosis model. In the control group, an equal volume of castor oil was injected subcutaneously. Rats in the treatment group also received 100 mg·kg(-1)·day(-1) flavonoid compounds via gastric tubes. After 6 weeks, rats were sacrificed, and their liver tissues were examined for pathological changes, including alanine aminotransferase, aspartate aminotransferase, total bilirubin, hyaluronic acid, laminin, and procollagen type-3. Liver tissues from control rats showed no significant pathological changes, while model animals showed significant liver fibrosis. In the treatment group, liver fibrosis significantly decreased compared to the model group (P < 0.05). Liver fibrotic indices, including hyaluronic acid, laminin, and procollagen type-3, in treatment rats were all significantly lower than those in the model group (P < 0.05), but not significantly different compared to the normal group (P > 0.05). Other liver function indices, including alanine aminotransferase, aspartate aminotransferase, and total bilirubin, in treatment rats were also significantly lower than those in model rats (P < 0.01) but higher than those in control animals (P < 0.05). Flavonoid compounds extracted from Iris plants showed significant inhibitory effects on CCl4-induced rat liver fibrosis. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-09-21 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Flavonoids Pharmacology Iris Plant Chemistry Liver Cirrhosis Prevention & Control Animals Carbon Tetrachloride Toxicity Disease Models, Animal Isolation & Purification Liver Drug Effects Pathology Chemically Induced Liver Function Tests Random Allocation Rats, Sprague-dawley Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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