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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Guo, H. Yang, H. J. Li, S. M. Lv, M. Q. Zhou, D. X. |
| Spatial Coverage | China |
| Description | Country affiliation: China Author Affiliation: Li SM ( Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.); Guo H ( Department of Emergency, Xi'an Jiaotong University Medical College Affiliated Red Cross Hospital, Xi'an, China.); Yang HJ ( Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.); Lv MQ ( Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, China.); Zhou DX ( Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, China zhoudx2010@163.com.) |
| Abstract | Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. Prompted by these findings, this study was designed to explore the associations between HLA-A gene polymorphisms and postmenopausal osteoporosis in the Han Chinese population. The polymerase chain reaction-sequence-based typing method was used for DNA genotyping at the HLA-A locus in 70 patients with postmenopausal osteoporosis and 73 healthy controls. We identified 17 HLA-A alleles in patients with postmenopausal osteoporosis and 20 HLA-A alleles in control subjects. Furthermore, we found that the frequency of the HLA-A* 02:07 allele was significantly higher in patients with postmenopausal osteoporosis than in control subjects (P = 0.023), and the relative risk was 4.065 (95% confidence interval = 1.109-14.893). Our study provides supportive evidence for the contribution of HLA-A gene polymorphisms to the susceptibility to postmenopausal osteoporosis and suggests that HLA-A* 02:07 is likely an important genetic risk factor for postmenopausal osteoporosis in the Han Chinese population. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-08-28 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Asian Continental Ancestry Group Genetics Ethnic Groups Genetic Predisposition To Disease Hla-a Antigens Polymorphism, Genetic Postmenopause Alleles Case-control Studies Gene Frequency Genetic Loci Linkage Disequilibrium Osteoporosis, Postmenopausal Blood Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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