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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pang, M. Sun, Y. H. He, W-N Zhang, W. H. Song, P. Y. Guo, Y. Sheng, L. J. |
| Description | Country affiliation: China Author Affiliation: Sun YH ( Affiliated Hospital of ShanDong Academy of Medical Sciences, Shandong, China.); Song PY ( Affiliated Hospital of ShanDong Academy of Medical Sciences, Shandong, China.); Guo Y ( Affiliated Hospital of ShanDong Academy of Medical Sciences, Shandong, China.); Pang M ( Affiliated Hospital of ShanDong Academy of Medical Sciences, Shandong, China.); He WN ( Affiliated Hospital of ShanDong Academy of Medical Sciences, Shandong, China.); Zhang WH ( Affiliated Hospital of ShanDong Academy of Medical Sciences, Shandong, China.); Sheng LJ ( Affiliated Hospital of ShanDong Academy of Medical Sciences, Shandong, China sunyahong_syh@163.com.) |
| Abstract | We aimed to analyze the changes of serum vascular endothelial growth factor (VEGF) before and after microwave ablation (MWA) in patients with stage IIIB-IV non-small cell lung cancer (NSCLC), and to observe the effects of MWA combined with chemotherapy on short-term therapeutic efficacy and long-term survival. Concentrations of serum VEGF in 20 healthy subjects were considered as controls. Changes of serum VEGF were detected by ELISA before and after MWA (1 and 7 days after treatment). Seven days after MWA, patients were divided into a combination chemotherapy group of 22 subjects and a MWA alone group of 18 subjects. Serum VEGF was measured 1 month after MWA and 4 cycles after chemotherapy (3 months) to evaluate term effects; and 1- and 2-year survival rates. Serum VEGF concentrations declined sharply 1 day after MWA, and were significantly different from the levels before treatment. Subsequently, VEGF rebounded 7 days after ablation, higher than that before treatment. At 1 and 3 months, serum VEGF levels in both treatment groups were remarkably lower than that before treatment; efficiency, or for the 1-year survival rate. However, the 2-year survival rates were significantly different between the two groups. We demonstrated that after MWA, the serum VEGF concentration undergoes a process of increasing, which might promote metastasis and recurrence of NSCLC. MWA combined with whole-body chemotherapy appears to be an effective method to increase the disease control rate, reduce the probability of metastasis and recurrence, and thus improve long-term survival. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-08-21 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Carcinoma, Non-small-cell Lung Blood Therapy Lung Neoplasms Microwaves Vascular Endothelial Growth Factor A Adverse Effects Diagnosis Mortality Case-control Studies Combined Modality Therapy Neoplasm Staging Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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