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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sun, L. Liu, J. Y. Li, L. R. |
| Spatial Coverage | China |
| Description | Country affiliation: China Author Affiliation: Sun L ( Department of Emergency, Linyi People's Hospital, Linyi, Shandong, China.); Liu JY ( Department of Pre-Hospital Emergency, Linyi People's Hospital, Linyi, Shandong, China.); Li LR ( Department of Pre-Hospital Emergency, Linyi People's Hospital, Linyi, Shandong, China.) |
| Abstract | Patients with obstructive sleep apnea syndrome (OSAS) have an increased risk for type 2 diabetes mellitus (T2DM). It has been recently demonstrated that serum YKL-40 levels, also named as human cartilage glycoprotein 39, are elevated in T2DM patients. The aim of this study was to determine whether serum YKL-40 levels are associated with T2DM in patients with OSAS. This study consisted of 432 patients with OSAS (234 and 198 patients with and without T2DM, respectively). Serum YKL-40 levels were examined using the enzyme-linked immunosorbent assay method. OSAS patients with T2DM had significantly elevated serum YKL-40 levels compared to those without T2DM [205.02 (146.16-272.70) vs 135.72 (114.06-163.38)]. According to the multivariable logistic regression analysis, serum YKL-40 levels were an independent determinant of T2DM in patients with OSAS. Furthermore, based on the linear regression analysis, serum YKL-40 levels were positively associated with the body mass index, systolic blood pressure, serum triglyceride levels, homeostasis model assessment of insulin resistance, and levels of C-reactive protein, fasting plasma glucose, 2-h postprandial plasma glucose, and HbA1c in patients with OSAS. Elevated serum YKL-40 levels may serve as a new biomarker to predict T2DM in patients with OSAS. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-08-03 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Adipokines Blood Diabetes Mellitus, Type 2 Complications Lectins Sleep Apnea, Obstructive Biological Markers Body Mass Index Body Weights And Measures Enzyme-linked Immunosorbent Assay Multivariate Analysis Regression Analysis Risk Factors Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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