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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, J. S. Li, Y. Q. Wang, P. Xie, Z. X. Ma, G. Y. Li, J. Wang, W. Z. Wang, L. |
| Description | Country affiliation: China Author Affiliation: Li J ( Department of Emergency, Harrison International Peace Hospital, Hengshui, China.); Wang JS ( Department of Emergency, Harrison International Peace Hospital, Hengshui, China.); Xie ZX ( Department of Emergency, Harrison International Peace Hospital, Hengshui, China.); Wang WZ ( Department of Emergency, Harrison International Peace Hospital, Hengshui, China.); Wang L ( Department of Emergency, Harrison International Peace Hospital, Hengshui, China.); Ma GY ( Department of Emergency, Harrison International Peace Hospital, Hengshui, China.); Li YQ ( Department of Emergency, Harrison International Peace Hospital, Hengshui, China.); Wang P ( Department of Emergency, Harrison International Peace Hospital, Hengshui, China.) |
| Abstract | This study evaluated the relationships among copeptin, ischemia-modified albumin (IMA), and extent of myocardial injury in patients with acute carbon monoxide poisoning (ACOP). A total of 110 patients with different degrees of ACOP were selected as the poisoning group, and 30 healthy individuals as the control group. The levels of troponin I (cTnI), IMA, and copeptin were detected. Based on the presence of complications, the patients were assigned to the complication (26 patients) or non-complication (84 patients) group. Levels of cTnI, IMA, and copeptin were compared among the control, complication, and non-complication groups. Compared with the control group, in the 2 h after admission, the IMA levels decreased and copeptin levels increased in the poisoning group; these changes were more significant in patients with severe ACOP than in those with mild ACOP, and the difference was statistically significant (P < 0.05). There were no differences in the IMA and copeptin levels between the groups 7 days after admission; the cTnI levels increased more significantly in patients with severe ACOP than in patients with mild and moderate ACOP, and the differences were statistically significant (P < 0.05). In the complication group, at 7 days after admission, the IMA levels decreased whereas the copeptin and cTnI levels were significantly higher than in the non-complication group, with a statistically significant difference (P < 0.05). IMA was negatively correlated with copeptin. IMA and copeptin detection is clinically useful in the early diagnosis and prognosis of ACOP-related myocardial injury and in guiding early clinical drug application. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-09-01 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Carbon Monoxide Poisoning Metabolism Glycopeptides Myocardium Pathology Serum Albumin Acute Disease Adolescent Biological Markers Troponin I Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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