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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhu, Y-K Li, J. Wang, K-F Jia, L. Zhang, J. Yu, H-W Meng, Q-H |
| Description | Country affiliation: China Author Affiliation: Zhang J ( Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.); Yu HW ( Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.); Li J ( Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.); Zhu YK ( Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.); Wang KF ( Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.); Jia L ( Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.); Meng QH ( Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China qinghuamengcn@163.com.) |
| Abstract | In liver cirrhosis with bacterial infection, hepatoadrenal syndrome has been described recently as a progressive impairment in the adrenocortical reserve, with deficient production or action of glucocorticoids resulting in adrenal insufficiency. The aim of this study was to explore the characteristics of cortisol in hepatitis B virus (HBV) cirrhosis patients in the absence of bacterial infection. Fasting peripheral venous blood samples were collected from 107 patients with HBV cirrhosis in the absence of bacterial infection and 18 patients with chronic hepatitis B (CHB) infection at 7 a.m. in the morning. The carbohydrate, cortisol-binding globulin, routine chemistry, liver function, and hepatitis B indicators were tested, and free cortisol was calculated. Cortisol (COR) levels were 18.72 ± 6.60 µg/dL in the CHB group and 14.20 ± 7.55 µg/dL in the HBV cirrhosis group (P = 0.002). COR levels were 15.11 ± 5.56, 14.88 ± 6.96, and 12.68 ± 8.36 µg/dL in Child-Pugh class A, B, and C cirrhotic patients, respectively (P = 0.006). Adrenocorticotropic hormone levels were 35.42 ± 24.49, 26.57 ± 15.72, and 19.65 ± 10.72 pg/mL in Child-Pugh class A, B, and C cirrhotic patients, respectively (P = 0.000). Patients with HBV cirrhosis had significantly lower serum COR levels compared with those of CHB patients, even if they are in the absence of bacterial infection. COR levels negatively correlated with Child-Pugh scores. The hypothalamic-pituitary-adrenal axis might be damaged in patients with HBV cirrhosis. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-07-17 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Bacterial Infections Complications Hepatitis B Virus Physiology Hepatitis B Blood Virology Hydrocortisone Liver Cirrhosis Adolescent Adrenocorticotropic Hormone Carrier Proteins Demography Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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