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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ding, M. Liu, D-W Mao, Y-G Liu, Y. Liu, Y-F Peng, Y. |
| Description | Country affiliation: China Author Affiliation: Liu YF ( First Affiliated Hospital of Nanchang University, Nanchang, China.); Ding M ( Guangzhou Integrated Traditional Chinese and Western Medicine Hospital, Guangzhou, China.); Liu DW ( First Affiliated Hospital of Nanchang University, Nanchang, China.); Liu Y ( First Affiliated Hospital of Nanchang University, Nanchang, China.); Mao YG ( First Affiliated Hospital of Nanchang University, Nanchang, China.); Peng Y ( First Affiliated Hospital of Nanchang University, Nanchang, China.) |
| Abstract | Despite years of effort, current therapies for diabetic wounds are still not fully efficacious. Emerging evidence has suggested that microRNAs (miRNAs) play key roles in multiple physiological and pathological processes in eukaryotes, and could potentially be powerful therapeutic tools. This study investigated the differential expression profiling of miRNAs in cutaneous wounds in streptozotocin-induced diabetic rats and normal rats, and its significance in diabetic wound healing. Using microarrays, 18 miRNAs were identified as being upregulated and 65 as being downregulated in the diabetic group. The miRNA profiling results were validated by quantitative reverse transcriptase polymerase chain reaction. Finally, functional annotation analysis using the DAVID and miR2Subpath databases revealed that the differentially expressed miRNAs were involved in MAPK signaling pathways, the Wnt signaling pathway, and other signaling pathways that may be closely linked to wound healing. This study provides an experimental foundation for further investigation of mechanisms that underlie poor diabetic wound healing, and of miRNA-based therapies that are associated with wound healing. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-08-14 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Diabetes Complications Diabetes Mellitus, Experimental Micrornas Genetics Transcriptome Wounds And Injuries Etiology Animals Computational Biology Gene Expression Profiling Gene Expression Regulation Molecular Sequence Annotation Phenotype Reproducibility Of Results Signal Transduction Skin Ulcer Metabolism Wound Healing Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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