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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, Bae-Jin Senevirathne, Mahinda Kim, Jin-Soo Kim, Young-Mog Lee, Myung-Suk Jeong, Min-Ho Kang, Young Mi Kim, Jung Il Nam, Byung-Hyouk Ahn, Chang-Bum Je, Jae-Young |
| Description | Author Affiliation: Lee BJ ( Marinebioprocess Co., Ltd., Busan 619-912, Republic of Korea.) |
| Abstract | Sea tangle has long been used as Korean folk remedy to promote material health, and is one of the popular dietary supplement. This study was designed to evaluate the protective effect of fermented sea tangle (FST) against ethanol and carbon tetrachloride (CCl(4))-induced hepatotoxicity in rats. Sprague-Dawley rats were orally treated with FST (25, 250, 2500 mg/kg/day) with administration of ethanol (5 mL/kg) for 13 weeks and the single intraperitoneal (i.p.) dose of 50% CCl(4) (5 mL/kg/day, CCl(4) in olive oil) at 12 week, and repeated i.p. dose of 20% CCl(4) (2 mL/kg/day) for 1 week. Hepatotoxicity was evaluated by measuring the serum levels of glutamic pyruvate transaminase (GPT), gamma glutamyl transpeptidase (gamma-GT) and malondialdehyde (MDA) as well as the tissue levels of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Ethanol and CCl(4)-induced the rat liver damage, and significantly increased (p<0.05) the GPT, gamma-GT and MDA levels, and decreased the SOD, CAT and GPx levels. However, treatment with FST could decrease serum GPT, gamma-GT, and MDA levels significantly in plasma, and increase the activities of SOD, CAT, and GPx in liver tissues compared with ethanol and CCl(4)-treated group. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 4 |
| Volume Number | 48 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Antioxidants Pharmacology Carbon Tetrachloride Toxicity Drug-induced Liver Injury Prevention & Control Ethanol Laminaria Chemistry Plant Extracts Alanine Transaminase Blood Animals Carbon Tetrachloride Poisoning Metabolism Pathology Fermentation Lipid Peroxidation Drug Effects Liver Liver Function Tests Male Oxidoreductases Rats Rats, Sprague-dawley Gamma-glutamyltransferase Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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