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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yin, C. C. Jiang, F. L. Liu, S. H. Wang, Z. S. Wu, L. Q. Han, S. Guo, W. G. |
| Spatial Coverage | China |
| Description | Country affiliation: China Author Affiliation: Wang ZS ( Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.); Yin CC ( Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao, China.); Han S ( Department of Hepatobiliary Surgery, Jiaozhou People Hospital, Qingdao, China.); Jiang FL ( Clinical Laboratory, Medical College, Qingdao University Qingdao, China.); Guo WG ( Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.); Wu LQ ( Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.); Liu SH ( Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, China.) |
| Abstract | In addition to the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. The macrophage migration inhibitory factor (MIF) -173G/C polymorphism (rs755622), located in the promoter region of MIF, may play integral roles in diverse processes, including the immune response. Thus, the MIF -173G/C polymorphism may influence the immune response to HBV during natural infection. We investigated whether the MIF -173G/C polymorphism was associated with susceptibility to HBV infection in a Chinese Han population. A total of 596 HBV infection cases and 612 age-matched controls were recruited for the study. Genotyping of the MIF -173G/C polymorphism was performed using the allele-specific polymerase chain reaction method. The frequencies of the alleles and genotypes in patients and controls were compared using the χ(2) test. Carriers of the variant C allele in MIF -173 G/C were at significantly higher risk of HBV infection than carriers of the wild-type allele (P = 0.032, odds ratio = 0.799, 95% confidence interval = 0.651-0.981). However, there was no significant difference in the distribution of MIF -173G/C genotypes between case and control groups in either population (P = 0.096, degrees of freedom = 2). Our findings indicate that the G to C base change in MIF -173 G/C confers an increased risk of development of HBV infection by altering the expression of MIF in our Chinese Han population. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-07-28 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Hepatitis B, Chronic Genetics Intramolecular Oxidoreductases Macrophage Migration-inhibitory Factors Asian Continental Ancestry Group Case-control Studies Gene Frequency Genetic Association Studies Genetic Predisposition To Disease Hepatitis B Virus Isolation & Purification Enzymology Odds Ratio Polymerase Chain Reaction Polymorphism, Single Nucleotide Promoter Regions, Genetic Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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