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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Su, X. L. Liang, J. Q. An, C. Y. Xi, Y. G. |
| Spatial Coverage | China |
| Description | Country affiliation: China Author Affiliation: Liang JQ ( Department of Cell Biology, Capital Medical University, Beijing, China.); Xi YG ( Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.); An CY ( Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.); Su XL ( Department of Cell Biology, Capital Medical University, Beijing, China.) |
| Abstract | Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotyping. The genotype distributions of all selected polymorphisms were consistent with Hardy-Weinberg equilibrium. The presence of the G allele in the rs7187932 polymorphism was found to be associated with an increased risk of hypertension (OR: 1.30; 95%CI = 1.00-1.38; P = 0.048), whereas the rs2399594 G allele was associated with a reduced risk for hypertension (OR: 0.76; 95%CI = 0.60-0.97; P = 0.030). No significant difference was observed for other alleles. Haplotype analysis revealed an association of the rs2399594 and rs711746 GG haplotype with a reduced risk for hypertension (OR: 0.76; 95%CI = 0.60-0.97; P = 0.029). No significant association was observed between other haplotypes and hypertension. These results suggest that the SLC12A3 gene is a susceptibility gene for hypertension in the Mongolian population. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-08-21 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Asian Continental Ancestry Group Genetics Genetic Variation Hypertension Solute Carrier Family 12, Member 3 Alleles Blood Pressure Cross-sectional Studies Genetic Association Studies Genetic Predisposition To Disease Haplotypes Physiopathology Odds Ratio Polymorphism, Single Nucleotide Population Surveillance Risk Factors Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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