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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schwarzman, A. L. Sarantseva, S. V. Rodin, D. I. |
| Description | Country affiliation: RUSSIA Author Affiliation: Rodin DI ( Molecular and Radiation Biophysics Division, National Research Centre 'Kurchatov Institute' B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russia rodin.dmitry@icloud.com.); Schwarzman AL ( Molecular and Radiation Biophysics Division, National Research Centre 'Kurchatov Institute' B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russia.) |
| Abstract | Amyloid precursor protein (APP) is a key player in Alzheimer's disease. The proteolytic cleavage of APP results in various short peptide fragments including the toxic amyloid-beta peptide, which is a main component of senile plaques. However, the functions of APP and its processed fragments are not yet well understood. Here, using real-time polymerase chain reaction, we demonstrate that exogenous expression of APP, its mutant form APP-Swedish, or two truncated forms in Drosophila melanogaster causes a significant (P ≤ 0.05) drop in the mRNA levels of the presynaptic proteins synaptotagmin-1 and neuronal synaptobrevin. The results obtained from this study suggest a potential role of APP or its fragments in the regulation of synaptic gene transcription. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-08-10 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Amyloid Beta-protein Precursor Genetics Drosophila Melanogaster Gene Expression Neurons Metabolism Presynaptic Terminals Rna, Messenger Animals Drosophila Proteins Presenilins R-snare Proteins Synaptotagmin I Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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