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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xue, L. Gao, W. Pang, W. Y. Li, D. D. Su, D. Y. |
| Description | Country affiliation: China Author Affiliation: Li DD ( Department of Endocrinology, Henan University Huaihe Hospital, Kaifeng, China.); Su DY ( Department of Endocrinology, Henan University Huaihe Hospital, Kaifeng, China.); Xue L ( Department of Endocrinology, Henan University Huaihe Hospital, Kaifeng, China.); Gao W ( Department of Endocrinology, Henan University Huaihe Hospital, Kaifeng, China.); Pang WY ( Department of Endocrinology, Henan University Huaihe Hospital, Kaifeng, China wuyanpang@126.com.) |
| Abstract | The aim of this study was to investigate the relationship between a lipoprotein lipase (LPL) gene polymorphism in placental tissue and insulin resistance (IR) in patients with gestational diabetes mellitus. Using polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP) analysis, the LPL HindIII RFLP was examined in the placental tissue of 110 patients with gestational diabetes mellitus (observation group) and 110 women with normal gestation (control group). The relationships between fasting plasma glucose (FPG), postprandial plasma glucose (PPG), fasting insulin (FINS), cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), body mass index (BMI), and IR indices and the LPL polymorphism in the two study groups and their offspring were determined. The frequency of the H+ allele was significantly higher in the observation group than in the controls (P < 0.05). There were statistically significant differences in the observation group between the FPG, PPG, LDL, TC, TG, HDL, BMI, FINS, and IR indices of the H+H+ group and those of the non H+H+ type patients (P < 0.05). Correlation analysis showed that the LPL gene polymorphism was positively related to IR. There were statistically significant differences between HDL, BMI, and IR indices between the two study groups (P < 0.05). In conclusion, the LPL gene polymorphism was determined to be the main factor related to IR in women with gestational diabetes, and was also found to be related to the IR of their offspring. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-07-14 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Diabetes, Gestational Enzymology Genetics Insulin Resistance Lipoprotein Lipase Placenta Polymorphism, Genetic Blood Genetic Predisposition To Disease Infant, Newborn Pregnancy Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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