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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ren, H. Y. Zhong, R. Ding, X. P. Jing, Y. L. Chen, Z. Y. |
| Spatial Coverage | China |
| Description | Country affiliation: China Author Affiliation: Ren HY ( Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China.); Zhong R ( Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China.); Ding XP ( Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China.); Chen ZY ( Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China.); Jing YL ( Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China.) |
| Abstract | Previous studies have shown that genetic polymorphisms in exon7 of the NSUN7 gene can be used as an infertility marker in Iranian men with asthenospermia. However, there have been no equivalent studies in China. In the present study, we investigated the possible association between the genetic polymorphisms in exon7 of NSUN7 and asthenospermia in a Chinese Han population. We recruited 240 asthenospermic men as a patient group and 256 normospermic men as a control group, and analyzed the semen parameters on the basis of World Health Organization (WHO) guidelines. The genetic polymorphisms in exon7 of NSUN7 were detected by DNA sequence analysis. The results were analyzed statistically and a P value < 0.05 was considered significant. There were two genetic polymorphisms, c.906C>T and c.922T>G, in exon7 of NSUN7. We found relatively similar genotypes and allele frequencies between the two groups (P = 0.928, P = 0.928, respectively). The combined genotypes of the two polymorphisms did not identify a haplotype associated with asthenospermia (P = 0.824, P = 0.824, respectively). Our findings revealed that genetic polymorphisms in exon7 of the NSUN7 gene are not associated with asthenospermia in Chinese Han men. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-08-10 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Asian Continental Ancestry Group Genetics Asthenozoospermia Exons Polymorphism, Single Nucleotide Alleles Case-control Studies Gene Frequency Genotype Haplotypes Sequence Analysis, Dna Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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