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MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cha, C-H Sohn, Y-H Oh, H-B Ko, S-Y Cho, M-C Kwon, O-J
Spatial Coverage	Korea
Description	Country affiliation: South Korea Author Affiliation: Cha CH ( Department of Laboratory Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, South Korea.)
Abstract	Major histocompatibility complex (MHC) class I chain-related gene B (MICB) is located within the human MHC class I region. The location of MICB in the MHC region may imply the presence of linkage disequilibrium with polymorphic MICA and human leukocyte antigen (HLA) loci. MICB is also polymorphic; however, MICB polymorphisms have not been investigated in Koreans. Using sequence-based typing (SBT), we estimated the allelic frequencies of MICB and haplotypes with MICA, HLA-B, and HLA-DRB1 at high resolution in a population of 139 unrelated Korean individuals. Eight MICB alleles were identified. The most frequent allele was MICB005:02/010 (57.2%), followed by 002 (11.5%), 004 (8.3%), 005:03 (8.3%), and 008 (6.8%). The most common two-locus haplotypes were MICB005:02/010-MICA010 (19.4%), MICB005:02/010-DRB115:01 (6.5%), and MICB005:02/010-B15:01 (10.4%); the most common three-locus haplotypes were B15:01-MICA010-MICB005:02/010 (5.8%) and MICA010-MICB005:02/010-DRB104:06 (10.4%); and the most common four-locus haplotype was B15:01-MICA010-MICB005:02/010-DRB104:06 (5.8%). This is the first study to provide information about MICB allele frequencies and haplotypes with HLA in Koreans. These study results should help understand mechanisms of disease association between the MICB locus and neighboring loci in Koreans.
File Format	HTM / HTML
ISSN	20592302
Issue Number	1
Volume Number	78
e-ISSN	20592310
Journal	Tissue Antigens
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-07-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Hla Antigens Genetics Histocompatibility Antigens Class I Polymorphism, Genetic Alleles Asian Continental Ancestry Group Ethnic Groups Gene Frequency Haplotypes Humans Korea Linkage Disequilibrium Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology and Allergy Immunology

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MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans.

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MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans.

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