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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Vasan, A.S.S. Doraiswami, R. Pecht, M. |
| Copyright Year | 2011 |
| Description | Author affiliation: Center for Advanced Life Cycle Engineering (CALCE), University of Maryland, College Park, MD, USA-20742 (Vasan, A.S.S.; Doraiswami, R.; Pecht, M.) |
| Abstract | This paper presents an approach for rapid, label-free, multiplexed detection of biomarkers using an array of RF MEMS shunt capacitors. We have demonstrated two parallel modes of sensing using a single RF MEMS shunt capacitor. Surface stress change and RF signal losses, due to specific biomolecular binding, are the two parallel sensing modes realized. The design and fabrication of RF MEMS shunt capacitor, and the associated signal readout are discussed. Bio-detection ability of an RF MEMS shunt capacitor is validated by detecting Staphylococcus Aureus using mouse monoclonal IgG3 proteins. The data indicated 50% change in the signal readout due to membrane deflection for 160μg/mL of S. aureus. We also propose a barcode approach for multiplexed detection of biomarkers using a distributed microfluidic embedded RF MEMS system is proposed. |
| Starting Page | 1412 |
| Ending Page | 1419 |
| File Size | 1618466 |
| Page Count | 8 |
| File Format | |
| ISBN | 9781612844978 |
| ISSN | 05695503 |
| e-ISBN | 9781612844985 |
| e-ISBN | 9781612844961 |
| DOI | 10.1109/ECTC.2011.5898697 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-05-31 |
| Publisher Place | Florida, USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Radio frequency Micromechanical devices Biomembranes Capacitors Biomarkers Surface impedance Capacitance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering |
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