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| Content Provider | PubMed Central |
|---|---|
| Author | Zhong, Dandan Wang, Hongkai Liu, Ming Li, Xuechen Huang, Ming Zhou, Hong Lin, Shuqian Lin, Zhibin Yang, Baoxue |
| Copyright Year | 2015 |
| Abstract | Ganoderma lucidum polysaccharide peptide (GLPP) scavenges oxygen free radicalsthat are a key factor in the pathogenesis of renal ischemia reperfusion injury(RIRI). The aim of this study was to determine whether GLPP could attenuate RIRI bycounteracting the oxidative stress. The mechanism involved was assessed by an invivo mouse RIRI model and an in vitro hypoxia/reoxygenation model,and tunicamycin-stimulated NRK-52E cells were used to explore the GLPP-mediatedalleviation of ER stress. Experimental results showed that renal dysfunction andmorphological damage were reduced in GLPP-treated group. The imbalance of redoxstatus was reversed and production of ROS was reduced by GLPP. RIRI-inducedmitochondrial- and ER stress-dependent apoptosis were dramatically inhibited inGLPP-treated group. Intriguingly, JNK activation in the kidney with RIRI orhypoxia/reoxygenation was inhibited by GLPP. These results suggest that theprotective effect of GLPP against RIRI may be due to reducing oxidative stress,alleviating the mitochondrial and ER stress-dependent apoptosis caused by excessiveROS. |
| Related Links | http://dx.doi.org/10.1038/srep16910 |
| Starting Page | 16910 |
| File Format | |
| ISSN | 20452322 |
| e-ISSN | 20452322 |
| Journal | Scientific Reports |
| Volume Number | 5 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2015-11-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Science and technology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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