NDLI: Mycobacterium-Infected Dendritic Cells Disseminate Granulomatous Inflammation

Content Provider	PubMed Central
Author	Harding, Jeffrey S. Aditya, Rayasam Schreiber, Heidi A. Fabry, Zsuzsanna Sandor, Matyas
Copyright Year	2015
Abstract	The disappearance and reformation of granulomas during tuberculosis has been described using PET/CT/X-ray in both human clinical settings and animal models, but the mechanisms of granuloma reformation during active disease remains unclear. Granulomas can recruit inflammatory dendritic cells (iDCs) that can regulate local T-cell responses and can carry bacteria into the lymph nodes, which is crucial for generating systemic T-cell responses against mycobacteria. Here, we report that a subset of mycobacterium-infected iDCs are associated with bacteria-specific T-cells in infected tissue, outside the granuloma, and that this results in the formation of new and/or larger multi-focal lesions. Mycobacterium-infected iDCs express less CCR7 and migrate less efficiently compared to the non-infected iDCs, which may support T-cell capture in granulomatous tissue. Capture may reduce antigen availability in the lymph node, thereby decreasing systemic priming, resulting in a possible regulatory loop between systemic T-cell responses and granuloma reformation. T-cell/infected iDCs clusters outside the granuloma can be detected during the acute and chronic phase of BCG and Mtb infection. Our studies suggest a direct role for inflammatory dendritic cells in the dissemination of granulomatous inflammation.
Related Links	http://dx.doi.org/10.1038/srep15248
Starting Page	15248
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	5
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-10-30
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mycobacterium-Infected Dendritic Cells Disseminate Granulomatous Inflammation

Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation

Granulomatous hypophysitis by Mycobacterium gordonae in a non HIV-infected patient

Plasmacytoid dendritic cells sense hepatitis C virus–infected cells, produce interferon, and inhibit infection

Enterovirus-Infected β-Cells Induce Distinct Response Patterns in BDCA1+ and BDCA3+ Human Dendritic Cells

Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions

Osteopontin expression by CD103− dendritic cells drives intestinal inflammation

Adipose Tissue Dendritic Cells Enhances Inflammation by Prompting the Generation of Th17 Cells

Plasmacytoid dendritic cells as guardians in hepatitis C virus–infected liver

Mycobacterium-Infected Dendritic Cells Disseminate Granulomatous Inflammation

Similar Documents

Mycobacterium-Infected Dendritic Cells Disseminate Granulomatous Inflammation

Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation

Granulomatous hypophysitis by Mycobacterium gordonae in a non HIV-infected patient

Plasmacytoid dendritic cells sense hepatitis C virus–infected cells, produce interferon, and inhibit infection

Enterovirus-Infected β-Cells Induce Distinct Response Patterns in BDCA1+ and BDCA3+ Human Dendritic Cells

Impact of Mycobacterium tuberculosis RD1-locus on human primary dendritic cell immune functions

Osteopontin expression by CD103− dendritic cells drives intestinal inflammation

Adipose Tissue Dendritic Cells Enhances Inflammation by Prompting the Generation of Th17 Cells

Plasmacytoid dendritic cells as guardians in hepatitis C virus–infected liver

Mycobacterium-Infected Dendritic Cells Disseminate Granulomatous Inflammation