NDLI: Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma

Content Provider	PubMed Central
Author	Li, Chenguang Gao, Zhibo Fei, Li Li, Xiangchun Sun, Yihua Wang, Mengyun Dan, Li Wang, Rui Li, Fuming Fang, Rong Pan, Yunjian Luo, Xiaoyang Jing, He Zheng, Liangtao Xia, Jufeng Qiu, Lixin Jun, He Ting, Ye Zhang, Ruoxin He, Minghui Zhu, Meiling Hu, Haichuan Shi, Tingyan Zhou, Xiaoyan Sun, Menghong Tian, Shilin Zhou, Yong Wang, Qiaoxiu Chen, Longyun Yin, Guangliang Lu, Jingya Wu, Renhua Guo, Guangwu Li, Yingrui Hu, Xueda Lin, Li Asan, A. Wang, Qin Yin, Ye Feng, Qiang Wang, Bin Wang, Hang Wang, Mingbang Yang, Xiaonan Zhang, Xiuqing Yang, Huanming Jin, Li Wang, Cun-yu Ji, Hongbin Chen, Haiquan Wang, Jun Wei, Qingyi
Copyright Year	2015
Abstract	Lung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding of mutational landscape for this subtype of lung cancer in Chinese patients is currently limited. We performed whole exome sequencing in samples from 100 patients with lung SQCCs to search for somatic mutations and the subsequent target capture sequencing in another 98 samples for validation. We identified 20 significantly mutated genes, including TP53, CDH10, NFE2L2 and PTEN. Pathways with frequently mutated genes included those of cell-cell adhesion/Wnt/Hippo in 76%, oxidative stress response in 21%, and phosphatidylinositol-3-OH kinase in 36% of the tested tumor samples. Mutations of Chromatin regulatory factor genes were identified at a lower frequency. In functional assays, we observed that knockdown of CDH10 promoted cell proliferation, soft-agar colony formation, cell migration and cell invasion, and overexpression of CDH10 inhibited cell proliferation. This mutational landscape of lung SQCC in Chinese patients improves our current understanding of lung carcinogenesis, early diagnosis and personalized therapy.
Related Links	http://dx.doi.org/10.1038/srep14237
Starting Page	14237
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	5
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-10-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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