NDLI: Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibitaggregation, disrupt fibrils and modulate toxicity of Wild type and Mutantα-Synuclein

Content Provider	PubMed Central
Author	Ahsan, Nuzhat Mishra, Satyendra Jain, Manish Kumar Surolia, Avadhesha Gupta, Sarika
Copyright Year	2015
Abstract	Accumulating evidence suggests that deposition of neurotoxic α-synucleinaggregates in the brain during the development of neurodegenerative diseases likeParkinson’s disease can be curbed by anti-aggregation strategies thateither disrupt or eliminate toxic aggregates. Curcumin, a dietary polyphenolexhibits anti-amyloid activity but the use of this polyphenol is limited owing toits instability. As chemical modifications in curcumin confiscate this limitation,such efforts are intensively performed to discover molecules with similar butenhanced stability and superior properties. This study focuses on the inhibitoryeffect of two stable analogs of curcumin viz. curcumin pyrazole and curcuminisoxazole and their derivatives against α-synuclein aggregation,fibrillization and toxicity. Employing biochemical, biophysical and cell basedassays we discovered that curcumin pyrazole (3) and its derivativeN-(3-Nitrophenylpyrazole) curcumin (15) exhibit remarkable potency in not onlyarresting fibrillization and disrupting preformed fibrils but also preventingformation of A11 conformation in the protein that imparts toxic effects. Compounds 3and 15 also decreased neurotoxicity associated with fast aggregating A53T mutantform of α-synuclein. These two analogues of curcumin described here maytherefore be useful therapeutic inhibitors for the treatment ofα-synuclein amyloidosis and toxicity in Parkinson’s diseaseand other synucleinopathies.
Related Links	http://dx.doi.org/10.1038/srep09862
Starting Page	9862
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	5
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-05-18
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein

Conversion of Wild-type α-Synuclein into Mutant-type Fibrils and Its Propagation in the Presence of A30P Mutant* S⃞

Conserved core of amyloid fibrils of wild type and A30P mutant α-synuclein

Conversion of Wild-type α-Synuclein into Mutant-type Fibrils and Its Propagation in the Presence of A30P Mutant

Effect of curcumin analogs onα-synuclein aggregation and cytotoxicity

The fold of α-synuclein fibrils

α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane

Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.

GINSENOSIDE RB1 INHIBITS FIBRILLATION AND TOXICITY OF ALPHA-SYNUCLEIN AND DISAGGREGATES PREFORMED FIBRILS

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibitaggregation, disrupt fibrils and modulate toxicity of Wild type and Mutantα-Synuclein

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