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| Content Provider | PubMed Central |
|---|---|
| Author | Yu, Hong-pei Xie, Jia-ming Bin, Li Sun, Yi-hui Gao, Quan-geng Ding, Zhi-hui Wu, Hao-rong Qin, Zheng-hong |
| Copyright Year | 2015 |
| Abstract | Previous study revealed that the protective effect of TIGAR in cell survival ismediated through the increase in PPP (pentose phosphate pathway) flux. However, itremains unexplored if TIGAR plays an important role in DNA damage and repair. Thisstudy investigated the role of TIGAR in DNA damage response (DDR) induced bygenotoxic drugs and hypoxia in tumor cells. Results showed that TIGAR was increasedand relocated to the nucleus after epirubicin or hypoxia treatment in cancer cells.Knockdown of TIGAR exacerbated DNA damage and the effects were partly reversed bythe supplementation of PPP products NADPH, ribose, or the ROS scavenger NAC. Furtherstudies with pharmacological and genetic approaches revealed that TIGAR regulatedthe phosphorylation of ATM, a key protein in DDR, through Cdk5. The Cdk5-AMT signalpathway involved in regulation of DDR by TIGAR defines a new role of TIGAR in cancercell survival and it suggests that TIGAR may be a therapeutic target forcancers. |
| Related Links | http://dx.doi.org/10.1038/srep09853 |
| Starting Page | 9853 |
| File Format | |
| ISSN | 20452322 |
| e-ISSN | 20452322 |
| Journal | Scientific Reports |
| Volume Number | 5 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2015-04-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Science and technology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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