NDLI: Dysregulated Ca2+ Homeostasis in Fanconi anemia cells

Content Provider	PubMed Central
Author	Usai, Cesare Ravera, Silvia Paola, Cuccarolo Isabella, Panfoli Dufour, Carlo Cappelli, Enrico Degan, Paolo
Copyright Year	2015
Abstract	Fanconi Anemia (FA) is a rare and complex inherited blood disorder associated with bone marrow failure and malignancies. Many alterations in FA physiology appear linked to red-ox unbalance including alterations in the morphology and structure of nuclei, intermediate filaments and mitochondria, defective respiration, reduced ATP production and altered ATP/AMP ratio. These defects are consistently associated with impaired oxygen metabolism indeed treatment with antioxidants N-acetylcysteine (NAC) and resveratrol (RV) does rescue FA physiology. Due to the importance of the intracellular calcium signaling and its key function in the control of intracellular functions we were interested to study calcium homeostasis in FA. We found that FANCA cells display a dramatically low intracellular calcium concentration ([Ca2+]i) in resting conditions. This condition affects cellular responses to stress. The flux of Ca2+ mobilized by H2O2 from internal stores is significantly lower in FANCA cells in comparison to controls. The low basal [Ca2+]i in FANCA appears to be an actively maintained process controlled by a finely tuned interplay between different intracellular Ca2+ stores. The defects associated with the altered Ca2+ homeostasis appear consistently overlapping those related to the unbalanced oxidative metabolism in FA cells underlining a contiguity between oxidative stress and calcium homeostasis.
Related Links	http://dx.doi.org/10.1038/srep08088
Starting Page	8088
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	5
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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