NDLI: Inactivation of group II intron RmInt1 in the Sinorhizobium meliloti genome

Content Provider	PubMed Central
Author	Dolores, Molina-sánchez María Toro, Nicolás
Copyright Year	2015
Abstract	Group II introns are self-splicing catalytic RNAs that probably originated in bacteria and act as mobile retroelements. The dispersal and dynamics of group II intron spread within a bacterial genome are thought to follow a selection-driven extinction model. Likewise, various studies on the evolution of group II introns have suggested that they are evolving toward an inactive form by fragmentation, with the loss of the intron 3′-terminus, but with some intron fragments remaining and continuing to evolve in the genome. RmInt1 is a mobile group II intron that is widespread in natural populations of Sinorhizobium meliloti, but some strains of this species have no RmInt1 introns. We studied the splicing ability and mobility of the three full-length RmInt1 copies harbored by S. meliloti 1021, and obtained evidence suggesting that specific mutations may lead to the impairment of intron splicing and retrohoming. Our data suggest that the RmInt1 copies in this strain are undergoing a process of inactivation.
Related Links	http://dx.doi.org/10.1038/srep12036
Starting Page	12036
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	5
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-07-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Dispersion of the RmInt1 group II intron in the Sinorhizobium meliloti genome upon acquisition by conjugative transfer

Dispersion of the RmInt1 group II intron in the Sinorhizobium meliloti genome upon acquisition by conjugative transfer

Splicing of the Sinorhizobium meliloti RmInt1 group II intron provides evidence of retroelement behavior

Splicing of the Sinorhizobium meliloti RmInt1 group II intron provides evidence of retroelement behavior

Potential for alternative intron–exon pairings in group II intron RmInt1 from Sinorhizobium meliloti and its relatives

Spread of the group II intron RmInt1 and its insertion sequence target sites in the plant endosymbiont Sinorhizobium meliloti

Complete Genome Sequence of the RmInt1 Group II Intronless Sinorhizobium meliloti Strain RMO17

Use of the computer-retargeted group II intron RmInt1 of Sinorhizobium meliloti for gene targeting

Excision of the Sinorhizobium meliloti Group II Intron RmInt1 as Circles in Vivo

Inactivation of group II intron RmInt1 in the Sinorhizobium meliloti genome

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