NDLI: Molecular Evolution of the Capsid Gene in Norovirus Genogroup I

Content Provider	PubMed Central
Author	Kobayashi, Miho Yoshizumi, Shima Kogawa, Sayaka Takahashi, Tomoko Ueki, Yo Shinohara, Michiyo Mizukoshi, Fuminori Tsukagoshi, Hiroyuki Sasaki, Yoshiko Suzuki, Rieko Shimizu, Hideaki Akira, Iwakiri Okabe, Nobuhiko Komei, Shirabe Hiroto, Shinomiya Kozawa, Kunihisa Kusunoki, Hideki Ryo, Akihide Kuroda, Makoto Katayama, Kazuhiko Kimura, Hirokazu
Copyright Year	2015
Abstract	We studied the molecular evolution of the capsid gene in all genotypes (genotypes 1–9) of human norovirus (NoV) genogroup I. The evolutionary time scale and rate were estimated by the Bayesian Markov chain Monte Carlo (MCMC) method. We also performed selective pressure analysis and B-cell linear epitope prediction in the deduced NoV GI capsid protein. Furthermore, we analysed the effective population size of the virus using Bayesian skyline plot (BSP) analysis. A phylogenetic tree by MCMC showed that NoV GI diverged from the common ancestor of NoV GII, GIII, and GIV approximately 2,800 years ago with rapid evolution (about 10−3 substitutions/site/year). Some positive selection sites and over 400 negative selection sites were estimated in the deduced capsid protein. Many epitopes were estimated in the deduced virus capsid proteins. An epitope of GI.1 may be associated with histo-blood group antigen binding sites (Ser377, Pro378, and Ser380). Moreover, BSP suggested that the adaptation of NoV GI strains to humans was affected by natural selection. The results suggested that NoV GI strains evolved rapidly and date back to many years ago. Additionally, the virus may have undergone locally affected natural selection in the host resulting in its adaptation to humans.
Related Links	http://dx.doi.org/10.1038/srep13806
Starting Page	13806
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	5
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-09-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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