NDLI: Systematic analysis of hematopoietic gene expression profiles for prognostic predictionin acute myeloid leukemia

Content Provider	PubMed Central
Author	Varn, Frederick S. Andrews, Erik H. Cheng, Chao
Copyright Year	2015
Abstract	Acute myeloid leukemia (AML) is a hematopoietic disorder initiated by theleukemogenic transformation of myeloid cells into leukemia stem cells (LSCs).Preexisting gene expression programs in LSCs can be used to assess theirtranscriptional similarity to hematopoietic cell types. While this relationship haspreviously been examined on a small scale, an analysis that systematicallyinvestigates this relationship throughout the hematopoietic hierarchy has yet to beimplemented. We developed an integrative approach to assess the similarity betweenAML patient tumor profiles and a collection of 232 murine hematopoietic geneexpression profiles compiled by the Immunological Genome Project. The resultinglineage similarity scores (LSS) were correlated with patient survival to assess therelationship between hematopoietic similarity and patient prognosis. This analysisdemonstrated that patient tumor similarity to immature hematopoietic cell typescorrelated with poor survival. As a proof of concept, we highlighted one cell typeidentified by our analysis, the short-term reconstituting stem cell, whose LSSs weresignificantly correlated with patient prognosis across multiple datasets, and showeddistinct patterns in patients stratified by traditional clinical variables. Finally,we validated our use of murine profiles by demonstrating similar results whenapplying our method to human profiles.
Related Links	http://dx.doi.org/10.1038/srep16987
Starting Page	16987
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	5
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-11-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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