NDLI: Universal behavior of hydrogels confined to narrow capillaries

Content Provider	PubMed Central
Author	Li, Yang Sarıyer, Ozan S. Ramachandran, Arun Panyukov, Sergey Rubinstein, Michael Eugenia, Kumacheva
Copyright Year	2015
Abstract	Flow of soft matter objects through one-dimensional environments is important inindustrial, biological and biomedical systems. Establishing the underlyingprinciples of the behavior of soft matter in confinement can shed light on itsperformance in many man-made and biological systems. Here, we report an experimentaland theoretical study of translocation of micrometer-size hydrogels (microgels)through microfluidic channels with a diameter smaller than an unperturbed microgelsize. For microgels with different dimensions and mechanical properties, under arange of applied pressures, we established the universal principles of microgelentrance and passage through microchannels with different geometries, as well as thereduction in microgel volume in confinement. We also show a non-monotonic change inthe flow rate of liquid through the constrained microgel, governed by itsprogressive confinement. The experimental results were in agreement with the theorydeveloped for non-linear biaxial deformation of unentangled polymer gels. Our workhas implications for a broad range of phenomena, including occlusion of bloodvessels by thrombi and needle-assisted hydrogel injection in tissue engineering.
Related Links	http://dx.doi.org/10.1038/srep17017
Starting Page	17017
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	5
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-11-24
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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