NDLI: Regional brain uptake of ketone bodies and glucose in elderly humans: A $^{11}C-acetoacetate$ and $^{18}F-FDG$ PET study

Content Provider	IEEE Xplore Digital Library
Author	Bentourkia, M. Tremblay, S. Fortier, M. Croteau, E. Sarrhini, O. Turcotte, E. Cunnane, S.
Copyright Year	2009
Description	Author affiliation: Departments of Medicine, 3001, 12 Avenue North, Université de Sherbrooke, Sherbrooke, Québec, Canada, J1H 5N4 (Fortier, M.; Cunnane, S.) \|\| Departments of Nuclear Medicin, 3001, 12 Avenue North, Université de Sherbrooke, Sherbrooke, Québec, Canada, J1H 5N4 (Bentourkia, M.; Tremblay, S.; Croteau, E.; Sarrhini, O.; Turcotte, E.)
Abstract	The brain relies on glucose as its primary energy substrate. However, ketone bodies, i.e. acetoacetate and hydroxybutyrate, are the main replacement fuels for brain activity during fasting or on a ketogenic (very high fat, low carbohydrate) diet. We report here a study of ketone and glucose metabolism in human brain in young (mean 26 years) and aged (mean 73 years) healthy individuals as measured with positron emission tomography (PET), using the radiotracers $^{11}C-acetoacetate$ and $^{18}F-fluorodeoxyglucose$ (FDG). Three blood samples were withdrawn during the two scans and were analyzed for plasma radioactivity and for concentration of acetoacetate, hydroxybutyrate and glucose. In the eighteen selected brain regions for this study, although the standard uptake values (SUV) were lower in the elderly subjects compared to the young subjects, the ratio of SUV in aged on young were almost similar in glucose and ketone metabolism. This protocol for brain fuel measurement by PET can be combined with treatment or on ketogenic diet to further study brain metabolism in neurodegenerative pathologies.
Starting Page	3943
Ending Page	3945
File Size	589785
Page Count	3
File Format	PDF
ISBN	9781424439614
ISSN	10957863
DOI	10.1109/NSSMIC.2009.5401943
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-10-24
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sugar Senior citizens Humans Biochemistry Positron emission tomography Fuels Aging Brain Blood Plasma measurements
Content Type	Text
Resource Type	Article

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