NDLI: Kinetic modeling of brain FDG data with input function derived from images by independent component analysis

Content Provider	IEEE Xplore Digital Library
Author	Berradja, K. Boughanmi, N. Bentourkia, M.
Copyright Year	2009
Description	Author affiliation: University of Mostaganem, Algeria (Berradja, K.) \|\| University of Oran, Algeria (Boughanmi, N.) \|\| Université de Sherbrooke, Canada (Bentourkia, M.)
Abstract	Blood (or plasma) input function is mandatory in quantitative Positron Emission Tomography (PET) imaging. The input function (IF) is usually determined by blood sampling from heated patient arm, by means of continuous blood sampling, or from population based IFs normalized with one or more samples. However, external blood sampling is invasive and is always subject to uncertainties due to the manipulations. IF could also be extracted by means of algorithms such as factor analysis and independent components especially in heart studies. In this work, we show that IF can be determined from the images of brain arteries in a study of regional cerebral metabolic rates of glucose (rCMRG) with 18F-fluorodeoxyglucose (FDG) in normal volunteers using Independent Component Analysis (ICA). A region of interest (ROI) was drawn around the artery in the image and decomposed into blood and tissue using ICA. The calculated IF is therefore corrected for spillover of radioactivity from tissue, then it is normalized with a single plasma sample to correct for partial volume and finally it is denoised with spectral analysis. The calculated IF with ICA is found comparable to IF manually determined, and rCMRG values obtained with ICA-IF and sampled IF differ by nearly 3%.
Starting Page	2920
Ending Page	2923
File Size	273451
Page Count	4
File Format	PDF
ISBN	9781424439614
ISSN	10957863
DOI	10.1109/NSSMIC.2009.5401614
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-10-24
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Kinetic theory Brain modeling Independent component analysis Blood Image sampling Plasmas Positron emission tomography Arteries Uncertainty Algorithm design and analysis
Content Type	Text
Resource Type	Article

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