NDLI: Performance evaluation of PETbox: A low cost bench top PET scanner dedicated to high throughput preclinical imaging

Content Provider	IEEE Xplore Digital Library
Author	Zhang, H. Vu, N.T. Bao, Q. Silverman, R.W. Stout, D.B. Taschereau, R. Berry-Pusey, B.N. Williams, D.A. Douraghy, A. Rannou, F.R. Phelps, M.E. Chatziioannou, A.F.
Copyright Year	2009
Description	Author affiliation: UCLA David Geffen School of Medicine, Crump Institute for Molecular Imaging, Los Angeles, CA, 90095 USA (Vu, N.T.; Bao, Q.; Silverman, R.W.; Stout, D.B.; Taschereau, R.; Berry-Pusey, B.N.; Williams, D.A.; Douraghy, A.; Rannou, F.R.; Chatziioannou, A.F.) \|\| UCLA David Geffen School of Medicine, Crump Institute for Molecular Imaging, Los Angeles, CA, 90095 USA, on leave from the Department of Biomedical Engineering, Tsinghua University, Beijing, 100084 China (Zhang, H.) \|\| Department de Ingenieria Informatica, Universidad de Santiago de Chile, 7251657 Santiago, Chile (Phelps, M.E.)
Abstract	PETbox is designed to be a low cost and easy to use bench top small animal PET scanner dedicated for high throughput quantitative pharmacokinetic and pharmacodynamic studies. To achieve this goal, the scanner is integrated with a complete animal management system that provides life support including reproducible positioning, temperature control, anesthesia, real-time monitoring of animal respiration and a pathogen barrier. This approach minimizes the overall cost and complexity of preclinical PET imaging and should enable non-imaging scientists to embrace the technology. The system uses two opposing detector heads, each one consisting of a pixilated BGO array coupled to two H8500 multi-channel photomultiplier tubes. The BGO crystals were segmented into 20 × 44 arrays with a pixel pitch of 2.2 mm and a total active area of 44 mm × 96.8 mm. Position and timing signals from the photomultiplier tube readout circuitry were connected to a field programmable gate array (FPGA) board with eight ADC channels, each running at 100MHz. Signal processing algorithms were developed for the FPGA to process received PET events and raw list-mode data were generated by the FPGA board and transferred to a host PC for storage. Basic system performance parameters were measured. The system has an average intrinsic spatial resolution of 1.72mm FWHM along detector long axis and 1.84mm FWHM along detector short axis. The coincidence timing resolution was measured to be 4.1ns FWHM. The average energy resolution of the crystals was 19.8% and the absolute sensitivity of the system was measured to be 3.8% at the center of the gantry. Initial imaging studies were also performed with live mice. A mouse tumor xenograft was imaged 1 hour after a 32uCi $[^{18}F]FDG$ injection for 20 minutes. 3D images were generated using a ML-EM method. Results demonstrate the capability and potential of the PETbox system for dedicated high throughput mouse studies such as biodistribution and organ uptake quantification.
Starting Page	4013
Ending Page	4016
File Size	280668
Page Count	4
File Format	PDF
ISBN	9781424439614
ISSN	10957863
DOI	10.1109/NSSMIC.2009.5401918
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-10-24
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Costs Positron emission tomography Throughput Field programmable gate arrays Animals Detectors Mice Photomultipliers Crystals Timing
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

System integration of the MiCES small animal PET scanner

Improving the performance of small planar detectors for dedicated PET instrument

Crystal-based coincidence timing calibration for PET scanner

Performance Evaluation of PETbox: A Low Cost Bench Top Preclinical PET Scanner

Initial evaluation of the Indiana small animal PET scanner

System electronics for the MiCES small animal PET scanner

Front-end Electronics Design based on Vernier Method for a High Resolution MicroPET

Coincidence time alignment for planar pixellated positron emission tomography detector arrays

Development of a data acquisition system for the MiCES small animal PET scanner

Performance evaluation of PETbox: A low cost bench top PET scanner dedicated to high throughput preclinical imaging

Similar Documents

System integration of the MiCES small animal PET scanner

Improving the performance of small planar detectors for dedicated PET instrument

Crystal-based coincidence timing calibration for PET scanner

Performance Evaluation of PETbox: A Low Cost Bench Top Preclinical PET Scanner

Initial evaluation of the Indiana small animal PET scanner

System electronics for the MiCES small animal PET scanner

Front-end Electronics Design based on Vernier Method for a High Resolution MicroPET

Coincidence time alignment for planar pixellated positron emission tomography detector arrays

Development of a data acquisition system for the MiCES small animal PET scanner

Performance evaluation of PETbox: A low cost bench top PET scanner dedicated to high throughput preclinical imaging