NDLI: Evaluation of equivalence of upslope method-derived myocardial perfusion index and transfer constant based on two-compartment tracer kinetic model

Content Provider	IEEE Xplore Digital Library
Author	Ichihara, T. George, R.T. Lima, J.A.C. Ikeda, Y. Lardo, A.C.
Copyright Year	2010
Description	Author affiliation: Faculty of Radiological Technology, Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan (Ichihara, T.) \|\| Department of Medicine, Division of Cardiology, and the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA (Lardo, A.C.) \|\| Toshiba Medical Systems Corporation, Otawara, Japan (Ikeda, Y.) \|\| Department of Medicine, Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA (George, R.T.) \|\| Department of Medicine, Division of Cardiology, and the Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA (Lima, J.A.C.)
Abstract	The purpose of this study was to describe the upslope method-derived myocardial perfusion index using the parameters based on a tracer kinetic model of iodixanol contrast agent and to validate this theoretically derived relationship using an ischemic canine model. The established modified Kety model was used to describe the extravascular diffusion of iodixanol contrast agent, which undergoes no cellular uptake or metabolism. This model consists of two functional compartments, one describing the vascular compartment and the second representing all myocardial capillaries, interstitium, and cells. These compartments are connected by two rate constants, K and k, which represent the first-order transfer constants from the left ventricular (LV) blood to myocardium and from myocardium to the vascular system, respectively. In the early phase after the arrival of contrast agent in the myocardium, the relationship between K and the concentrations of iodixanol contrast agent in the myocardium and arterial blood (LV blood) is described by K = {dC) (Eq. 1), where C(t) is the relative concentration of iodixanol contrast agent in the myocardium at time t, C(t) is the relative concentration of iodixanol contrast agent in the LV blood, and t is the time at the peak of C(t) and maximum upslope of C(t). Six canine models of left anterior descending (LAD) artery stenosis were prepared and underwent first-pass contrast-enhanced mult-detector row computed tomography (MDCT) perfusion imaging during adenosine infusion (0.14–0.21 mg/kg/min) to study a wide range of flow rates. K was measured using the Patlak plot method and upslope method applied to time-attenuation curve data of the LV blood pool and myocardium. The results were compared against microsphere myocardial blood flow measurements. The Patlak plot-derived K and upslope method-derived K showed a good linear association. Regional K can be measured accurately using the upslope method-derived myocardial perfusion index based on a compartment model.
Starting Page	2330
Ending Page	2333
File Size	431954
Page Count	4
File Format	PDF
ISBN	9781424491063
ISSN	10957863
e-ISBN	9781424491056
DOI	10.1109/NSSMIC.2010.5874200
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Myocardium Indexes Biomedical imaging Computed tomography Blood Blood flow
Content Type	Text
Resource Type	Article

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