NDLI: Optical demonstration of a medical imaging system with an EMCCD-sensor array for use in a high resolution dynamic X-ray imager

Content Provider	IEEE Xplore Digital Library
Author	Bin Qu Ying Huang Weiyuan Wang Sharma, P. Kuhls-Gilcrist, A.T. Cartwright, A.N. Titus, A.H. Bednarek, D.R. Rudin, S.
Copyright Year	2010
Description	Author affiliation: Departments of Electrical Engineering and Biomedical Engineering, University at Buffalo, Buffalo NY 14260 USA (Cartwright, A.N.; Titus, A.H.) \|\| Departments of Physiology and Biophysics, University at Buffalo, Buffalo NY 14214 USA (Weiyuan Wang) \|\| Toshiba Stroke research center, University at Buffalo, Buffalo NY 14214 USA (Kuhls-Gilcrist, A.T.) \|\| Departments of Radiology, Neurosurgery, Physiology and Biophysics, University at Buffalo, Buffalo NY 14214 USA (Bednarek, D.R.) \|\| Departments of Radiology, Mechanical and Aerospace Engineering, Electrical Engineering, Biomedical Engineering, Physiology and Biophysics, and Neurosurgery, University at Buffalo, Buffalo NY 14214 USA (Rudin, S.) \|\| Department of Electrical Engineering, University at Buffalo, Buffalo, NY 14260 USA (Bin Qu; Ying Huang; Sharma, P.)
Abstract	Use of an extensible array of Electron Multiplying CCDs (EMCCDs) in medical x-ray imager applications was demonstrated for the first time. The large variable electronic-gain (up to 2000) and small pixel size of EMCCDs provide effective suppression of readout noise compared to signal, as well as high resolution, enabling the development of an x-ray detector with far superior performance compared to conventional x-ray image intensifiers and flat panel detectors. We are developing arrays of EMCCDs to overcome their limited field of view (FOV). In this work we report on an array of two EMCCD sensors running simultaneously at a high frame rate and optically focused on a mammogram film showing calcified ducts. The work was conducted on an optical table with a pulsed LED bar used to provide a uniform diffuse light onto the film to simulate x-ray projection images. The system can be selected to run at up to 17.5 frames per second or even higher frame rate with binning. Integration time for the sensors can be adjusted from 1 ms to 1000 ms. Twelve-bit correlated double sampling AD converters were used to digitize the images, which were acquired by a National Instruments dual-channel Camera Link PC board in real time. A user-friendly interface was programmed using LabVIEW to save and display 2K × 1K pixel matrix digital images. The demonstration tiles a 2 × 1 array to acquire increased-FOV stationary images taken at different gains and fluoroscopic-like videos recorded by scanning the mammogram simultaneously with both sensors. The results show high resolution and high dynamic range images stitched together with minimal adjustments needed. The EMCCD array design allows for expansion to an M×N array for arbitrarily larger FOV, yet with high resolution and large dynamic range maintained.
Starting Page	2607
Ending Page	2609
File Size	525729
Page Count	3
File Format	PDF
ISBN	9781424491063
ISSN	10957863
e-ISBN	9781424491056
DOI	10.1109/NSSMIC.2010.5874260
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Arrays X-ray imaging Image resolution Optical sensors Optical films
Content Type	Text
Resource Type	Article

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