NDLI: Analysis of the minimum detectable activity of a small animal scanner

Content Provider	IEEE Xplore Digital Library
Author	Lajtos, I. Emri, M. Kis, S.A. Opposits, G. Molnar, J. Balkay, L.
Copyright Year	2010
Description	Author affiliation: Institute of Nuclear Medicine, University of Debrecen, Hungary (Lajtos, I.; Emri, M.; Kis, S.A.; Opposits, G.; Balkay, L.) \|\| Institute of Nuclear Research of the Hungarian Academy of Sciences, Debrecen, Hungary (Molnar, J.)
Abstract	The examination of small animals using high resolution in-vivo imaging methods is a crucial tool in pharmaceutical research projects. These type of studies frequently require the measurement of very low activity lesions in a background region or high activity body parts for instance in case of dynamic investigations. To suffice these demands, two independent qualities of the PET scanner need to be appropriate, the low count detectability and the count rate performance. In our study we investigated the detectability of the low level activity area using our LYSO based small animal PET camera. The minimum detectable activity (MDA) was evaluated by the Currie equation and by taking into account the scanner recovery coefficient for different source diameters. We used two different water fillable cylindrical phantoms, the radius and the length of the cylinders are 15 mm and 50 mm, respectively. The phantom I includes five teflon (water density) rods with different diameter (0.5, 1.5, 2.5, 4, 6.5 mm). The phantom II includes tree glass rods with diameter of 0.5 mm. Filling the same F18 activity concentration to the rods of phantom I., the background (cylinder) region we injected C11 activity. This way we could examine different target to background ratios (T/B) simply. We found that the MDA depends on the actual background level and the size of the object. We also found that only the RC corrected $MDA^{∗}$ values and related points correspond to the real detectability (visibility). The smallest rod (diameter = 0.5 mm) could not be imaged by our mini PET scanner with the activity range we used in this study.
Starting Page	2224
Ending Page	2227
File Size	542216
Page Count	4
File Format	PDF
ISBN	9781424491063
ISSN	10957863
e-ISBN	9781424491056
DOI	10.1109/NSSMIC.2010.5874178
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Phantoms Positron emission tomography Pixel Animals Visualization Glass Equations
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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