NDLI: Evaluation of attenuation and scatter correction requirements as a function of object size in PET small animal imaging

Content Provider	IEEE Xplore Digital Library
Author	Konik, A. Koesters, T. Madsen, M.T. Sunderland, J.J.
Copyright Year	2010
Description	Author affiliation: European Institute for Molecular Imaging, University of Muenster, Muenster, Germany (Koesters, T.) \|\| University of Iowa Radiology Department, IA 52242 USA (Madsen, M.T.; Sunderland, J.J.) \|\| University of Massachusetts Medical School Radiology Department, MA 01655 USA (Konik, A.)
Abstract	In human emission tomography, an additional transmission scan is often required to obtain accurate attenuation maps for attenuation correction (AC) and scatter correction (SC). These methods have been translated to small animal imaging, although the impact of photon interactions on the reconstruction of mouse/rat images is substantially less than that in human imaging. In this study, we evaluate the requirement of these corrections for PET small animal imaging through Monte Carlo simulations of the Inveon PET scanner using MOBY voxelized phantoms scaled to different sizes (2.1–6.4 cm diameters). The 3D data were reconstructed in 6 different conditions depending on the attenuation map used: Accurate AC+SC, Simple AC+SC, Accurate AC only, Simple AC only, SC only and No correction. Mean error% for 8 different ROIs and 6 different MOBY sizes were obtained against the accurate reconstruction (first on the list). In addition, real mouse data obtained from an Inveon PET scanner were analyzed using similar methods. The results from simulations and real mouse data showed that attenuation correction based on solely emission data should be sufficient for imaging animals smaller than 4 cm diameter.
Starting Page	3458
Ending Page	3465
File Size	1352733
Page Count	8
File Format	PDF
ISBN	9781424491063
ISSN	10957863
e-ISBN	9781424491056
DOI	10.1109/NSSMIC.2010.5874449
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Attenuation Image reconstruction Positron emission tomography Mice Phantoms
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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