NDLI: Quantitative 3D evaluation of myocardial perfusion during regadenoson stress using multidetector computed tomography

Content Provider	IEEE Xplore Digital Library
Author	Mor-Avi, V. Kachenoura, N. Lodato, J.A. Chandra, S. Freed, B.H. Newby, B. Lang, R.M. Patel, A.R.
Copyright Year	2012
Description	Author affiliation: University of Chicago, Department of Medicine, Chicago, Illinois, USA (Mor-Avi, V.; Kachenoura, N.; Lodato, J.A.; Chandra, S.; Freed, B.H.; Newby, B.; Lang, R.M.; Patel, A.R.)
Abstract	We tested the hypothesis that quantitative 3D analysis of myocardial perfusion from MDCT images obtained during regadenoson stress would more accurately detect the presence of significant coronary artery disease (CAD) than the same analysis when performed on resting MDCT images. Fifty consecutive patients referred for CT coronary angiography (CTCA) underwent additional imaging with regadenoson (0.4mg, Astellas) using prospective gating (256-channel, Philips). Custom software was used to calculate for each myocardial segment an index of severity and extent of perfusion abnormality, Qh, which was compared to perfusion defects predicted by the presence and severity of coronary stenosis on CTCA. In segments supplied by arteries with luminal narrowing >50%, myocardial attenuation was slightly reduced compared to normally perfused segments at rest (91±21 vs. 93±26 HU, NS), and to a larger extent at stress (102±21 vs. 112±20 HU, p<0.05). In contrast, index Qh was significantly increased in these segments at rest (0.40±0.48 vs. 0.26±0.41, p<0.05) and reached a nearly 3-fold difference at stress (0.66±0.74 vs. 0.28±0.51, p<0.05). The addition of regadenoson improved the diagnosis of CAD, as reflected by an increase in sensitivity (from 0.57 to 0.91) and improvement in accuracy (0.65 to 0.77). In conclusion, quantitative 3D analysis of MDCT images allows objective detection of CAD, the accuracy of which is improved by regadenoson stress.
Starting Page	373
Ending Page	376
File Size	315597
Page Count	4
File Format	PDF
ISBN	9781467320764
ISSN	2325887X
e-ISBN	9781467320771
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-09-09
Publisher Place	Poland
Access Restriction	Subscribed
Rights Holder	Creative Commons Attribution License 2.5 (CCAL)
Subject Keyword	Stress Myocardium Attenuation Computed tomography Indexes Arteries
Content Type	Text
Resource Type	Article
Subject	Computer Science Cardiology and Cardiovascular Medicine

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