NDLI: Thick monolithic scintillation crystals for TOF-PET with depth-of-interaction measurement

Content Provider	IEEE Xplore Digital Library
Author	Vinke, R. van Dam, H.T. Seifert, S. Beekman, F.J. Lohner, H. Schaart, D.R. Dendooven, P.
Copyright Year	2010
Description	Author affiliation: KVI, University of Groningen, Zernikelaan 25, 9747 AA Groningen, The Netherlands (Vinke, R.; Lohner, H.; Dendooven, P.) \|\| Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands (van Dam, H.T.; Seifert, S.; Beekman, F.J.; Schaart, D.R.)
Abstract	Positron emission tomography (PET) detectors based on monolithic scintillation crystals show excellent intrinsic spatial resolution and allow depth-of-interaction (DOI) reconstruction using a single photosensor array. The inclusion of time-of-flight (TOF) information in the image reconstruction significantly reduces the image noise variance, effectively increasing the PET system sensitivity. For optimal detection efficiency, thick crystals are needed. However, the attainable spatial resolution decreases as the crystal thickness is increased. A maximum-likelihood-estimation (MLE) algorithm was developed to determine the 3D gamma interaction position. We present results on positioning and timing performance vs. crystal thickness for three monolithic LYSO crystals (16.2 mm × 18 mm × z, z = 10 mm, 15 mm, or 20 mm) coupled to a multi-anode photomultiplier (MA-PMT). The positioning performance varied with the distance to the MA-PMT. For the 20 mm thick LYSO crystal the position resolution parallel to the MA-PMT varied between 2.5 and 4.5 mm FWHM with the distance, while the DOI could be reconstructed with a resolution varying between 2 and 5 mm FWHM. For the 20 mm thick LYSO crystal in coincidence with a fast BaF detector, a coincidence resolving time (CRT) of 324 ps FWHM was obtained using digital time pickoff. We observed a signal propagation time variation with gamma interaction position from 30 ps for the 10 mm thick crystal to 65 ps for the 20 mm thick crystal. We conclude that thick monolithic scintillation crystals for optimal detection efficiency show very good timing resolution, which hardly degrades when increasing the crystal thickness from 10 mm to 20 mm, and allow for accurate position reconstruction (including DOI) at minimal detector costs (using a single photosensor array to read out the crystal).
Starting Page	1981
Ending Page	1984
File Size	244675
Page Count	4
File Format	PDF
ISBN	9781424491063
ISSN	10957863
e-ISBN	9781424491056
DOI	10.1109/NSSMIC.2010.5874121
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Crystals Detectors Timing Spatial resolution Arrays Signal resolution Energy resolution
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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