NDLI: Organ concentration quantification for small animal PET images by registration with a statistical mouse atlas

Content Provider	IEEE Xplore Digital Library
Author	Hongkai Wang Stout, D.B. Chatziioannou, A.F.
Copyright Year	2010
Description	Author affiliation: Crump Institute of Molecular Imaging, David Geffen School of Medicine, UCLA, USA (Hongkai Wang; Stout, D.B.; Chatziioannou, A.F.)
Abstract	This study focuses on quantification of probe concentration in major organs of small animal micro-PET images. In order to delineate organ ROIs, a statistical mouse atlas is registered to the micro-PET image. This statistical atlas is trained from 22 organ-labeled micro-CT images using Principle Component Analysis (PCA). By tuning the shape-controlling parameters of the atlas, we are able to adapt the atlas anatomy to fit the individual subject of the micro-PET image. To reduce the spillover effect, voxel confidence values are computed and are used to calculate confidence-weighted mean concentration of each organ. Experiments were performed on both simulated images and in-vivo micro-PET emission images. Results showed that the registration-based yielded comparable accuracy to the quantification based-on ground truth organ regions, and the confidence-weighted averaging obtains more accurate results than direct averaging of organ concentrations.
Starting Page	2092
Ending Page	2094
File Size	478621
Page Count	3
File Format	PDF
ISBN	9781424491063
ISSN	10957863
e-ISBN	9781424491056
DOI	10.1109/NSSMIC.2010.5874146
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Delta modulation Positron emission tomography Mice Shape Image segmentation Imaging phantoms
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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