NDLI: Is SPECT or CT based attenuation correction more quantitatively accurate for dedicated breast SPECT acquired with non-traditional trajectories?

Content Provider	IEEE Xplore Digital Library
Author	Perez, K.L. Mann, S.D. Pachon, J.H. Madhav, P. Tornai, M.P.
Copyright Year	2010
Description	Author affiliation: Biomedical Engineering and Radiology Departments, Duke University, Durham, NC 27710 USA (Madhav, P.) \|\| Medical Physics Program and Radiology Department, Duke University, Durham, NC 27710 USA (Perez, K.L.; Mann, S.D.; Pachon, J.H.; Tornai, M.P.)
Abstract	Attenuation correction is necessary for SPECT quantification. There are a variety of methods to create attenuation maps. For dedicated breast SPECT-CT imaging, it is unclear if either a SPECT- or CT-based attenuation map would provide the most accurate quantification and whether or not segmenting the different tissue types will have an effect on the quantification. For these experiments, $^{99m}Tc$ diluted in methanol and water filled geometric and anthropomorphic breast phantoms was imaged with a dedicated dual-modality SPECT-CT breast scanner. SPECT images were collected using a compact CZT camera with various 3D acquisition trajectories including vertical and 30° tilted parallel beam, and complex sinusoidal trajectories. CT images were acquired using a quasi-monochromatic x-ray source and CsI(T1) digital flat panel detector in a half-cone beam geometry. Measured scatter correction for SPECT and CT were implemented. To compare photon attenuation correction in the reconstructed SPECT images, various volumetric attenuation maps were derived from 1) uniform SPECT, 2) uniform CT, and 3) segmented CT, populated with different attenuation coefficient values. Comparisons between attenuation masks using phantoms consisting of materials with different attenuation values show that at 140 keV the differences in the attenuation between materials do not affect the quantification as much as the size and alignment of the attenuation map. The CT-based attenuation maps give quantitative values 30% below the actual value, but are consistent. The SPECT-based attenuation maps can provide within 10% accurate quantitative values, but are less consistent.
Starting Page	2319
Ending Page	2324
File Size	1515466
Page Count	6
File Format	PDF
ISBN	9781424491063
ISSN	10957863
e-ISBN	9781424491056
DOI	10.1109/NSSMIC.2010.5874198
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Attenuation Image reconstruction Computed tomography Methanol Breast Trajectory Phantoms
Content Type	Text
Resource Type	Article

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