NDLI: VLSI Implementation of a Nonlinear Neuronal Model: A "Neural Prosthesis" to Restore Hippocampal Trisynaptic Dynamics

Content Provider	IEEE Xplore Digital Library
Author	Min-Chi Hsiao Chiu-Hsien Chan Srinivasan, V. Ahuja, A. Erinjippurath, G. Zanos, T.P. Gholmieh, G. Dong Song Wills, J.D. LaCoss, J. Courellis, S. Tanguay, A.R. Granacki, J.J. Marmarelis, V.Z. Berger, T.W.
Copyright Year	2006
Description	Author affiliation: Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA (Min-Chi Hsiao)
Abstract	We are developing a biomimetic electronic neural prosthesis to replace regions of the hippocampal brain area that have been damaged by disease or insult. We have used the hippocampal slice preparation as the first step in developing such a prosthesis. The major intrinsic circuitry of the hippocampus consists of an excitatory cascade involving the dentate gyrus (DG), CA3, and CA1 subregions; this trisynaptic circuit can be maintained in a transverse slice preparation. Our demonstration of a neural prosthesis for the hippocampal slice involves: (i) surgically removing CA3 function from the trisynaptic circuit by transecting CA3 axons, (ii) replacing biological CA3 function with a hardware VLSI (very large scale integration) model of the nonlinear dynamics of CA3, and (iii) through a specially designed multi-site electrode array, transmitting DG output to the hardware device, and routing the hardware device output to the synaptic inputs of the CA1 subregion, thus by-passing the damaged CA3. Field EPSPs were recorded from the CA1 dendritic zone in intact slices and "hybrid" DG-VLSI-CA1 slices. Results show excellent agreement between data from intact slices and transected slices with the hardware-substituted CA3: propagation of temporal patterns of activity from DGrarrVLSIrarrCA1 reproduces that observed experimentally in the biological DGrarrCA3rarrCA1 circuit
Sponsorship	IEEE EMB
Starting Page	4396
Ending Page	4399
File Size	493548
Page Count	4
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.260138
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Very large scale integration Prosthetics Circuits Hardware Biomimetics Brain Diseases Neural prosthesis Hippocampus Surgery
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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