NDLI: Multisite interstitial stimulation for cardiac micro-impedance measurements

Content Provider	IEEE Xplore Digital Library
Author	Pollard, A.E. Barr, R.C.
Copyright Year	2006
Description	Author affiliation: Biomed. Eng. & Cardiac Rhythm Manage. Lab., Alabama Univ., Birmingham, AL (Pollard, A.E.)
Abstract	On theoretical grounds, interstitial current injected and removed using electrodes in close proximity does not cross the membrane, while equilibration of intracellular and interstitial potentials occurs distant from electrodes widely separated. Multisite interstitial stimulation should therefore give rise to interstitial potential differences recorded centrally that depend on intracellular and interstitial micro-impedances, allowing independent measurement. We tested the feasibility of completing such measurements using simulations of multisite stimulation with fine and wide spacing in models that included Luo-Rudy dynamic (LRd) membrane equations. Using two-dimensional models, test data $(deltaphi_{0})$ were generated with isotropic interstitial and intracellular micro-impedances prescribed for one set of simulations, and with anisotropic micro-impedances including unequal ratios (intracellular/interstitial) along and across fibers prescribed for another set of simulations. Micro-impedance measurements were then obtained by making statistical comparisons between $deltaphi_{0}$ values and interstitial potential differences from passive bidomain simulations (Deltaphi $_{0})$ in which a wide range of possible micro-impedances were considered. Our findings suggest development of microfabricated devices to implement the multisite stimulation procedure would facilitate routine measurement as a component of cardiac electrophysiologic study
Sponsorship	IEEE EMB
Starting Page	1572
Ending Page	1575
File Size	456319
Page Count	4
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.260244
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Biomembranes Equations Electrophysiology Mathematical model Virtual manufacturing Testing Anisotropic magnetoresistance Analytical models Cities and towns
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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