NDLI: Detection of murine infarcts using myocardial elastography at both high temporal and spatial resolution

Content Provider	IEEE Xplore Digital Library
Author	Luo, J. Fujikura, K. Konofagou, E.E.
Copyright Year	2006
Description	Author affiliation: Dept. of Biomed. Eng., Columbia Univ., New York, NY (Luo, J.; Fujikura, K.; Konofagou, E.E.)
Abstract	Myocardial elastography is a novel method for noninvasively assessing regional myocardial function, with the advantages of high spatial/temporal resolution, high signal-to-noise ratio and angle-independence. In this paper, in vivo experiments were performed in anesthetized normal and infarcted mice using a high-resolution ultrasound system. Radio-frequency signals were acquired at a high frame rate (up to 8000 Hz) and used to estimate the incremental axial displacements and strains of myocardium. The incremental results were further used to calculate the cumulative displacements and strains. Two-dimensional displacement and strain images (elastograms), M-mode displacement and strain images as well as displacement and strain profiles as a function of time clearly indicated the contraction and relaxation, thickening and thinning of myocardium and demonstrated the lower motion and deformation of infarcted myocardium. The cumulative displacement and strain were less noisy than incremental images, and the cumulative strain images show the highest contrast between non-infarcted and infarcted myocardia. Finally, preliminary statistical results from nine non-infarcted mice and seven infarcted mice indicated that cumulative strain can be used to differentiate infarcted myocardium from non-infarcted myocardium. In conclusion, myocardial elastography can provide strain information at both high temporal and spatial resolution, and is capable of accurately characterizing normal myocardial function as well as detecting and localizing early myocardial infarction in vivo
Sponsorship	IEEE EMB
Starting Page	1552
Ending Page	1555
File Size	398370
Page Count	4
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.259868
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Myocardium Spatial resolution Capacitive sensors Ultrasonic imaging Radio frequency Signal resolution Mice Tagging High-resolution imaging Image coding
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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