NDLI: Reconstruction of Spatially Resolved Pharmacokinetic Rate Images of Fluorescence Agents in FDOT

Content Provider	IEEE Xplore Digital Library
Author	Alacam, B. Yaziei, B. Serdaroglu, A. Intes, X. Chance, B. Nioka, S.
Copyright Year	2006
Description	Author affiliation: Dept. of Electr. Comput. & Syst. Eng., Rensselaer Polytech. Inst., Troy, NY (Alacam, B.; Yaziei, B.; Serdaroglu, A.)
Abstract	In this work, we propose a method to reconstruct spatially resolved pharmacokinetic rate images of fluorescence agents directly from the boundary photon flux measurements. We use a compartmental modeling scheme to model the pharmacokinetics of fluorescence agents. We coupled this model with the fluorescence diffuse optical tomography (FDOT) forward model to form a state space model which is then iteratively solved by extended Kalman filtering (EKF) algorithm. As an example, we used a two-compartment model for indocyanine green (ICG) pharmacokinetics. To validate the proposed method, we tested our approach using a simulation study. Reconstructed pharmacokinetic rate images with correct localization of heterogeneities and high reconstruction accuracy show that the proposed algorithm can be used for tumor detection, tumor diagnosis, drug delivery and feasibility studies
Sponsorship	IEEE EMB
Starting Page	5627
Ending Page	5630
File Size	176790
Page Count	4
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.259382
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Image reconstruction Spatial resolution Image resolution Fluorescence Optical filters Optical coupling Tomography State-space methods Kalman filters Filtering
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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