NDLI: Electrocardiographic Method for Identifying Drug-induced Repolarization Abnormalities Associated with a Reduction of the Rapidly Activating Delayed Rectifier Potassium Current

Content Provider	IEEE Xplore Digital Library
Author	Couderc JP Vaglio, M. Xia, X. McNitt, S. Hyrien, O.
Copyright Year	2006
Description	Author affiliation: Rochester Univ., NY (Couderc JP; Vaglio, M.; Xia, X.; McNitt, S.; Hyrien, O.)
Abstract	Several important non-cardiac drugs have been removed from the market after revealing harmful effect that was not identified during prior safety-assessment studies. We developed a new technique for the measurements of repolarization abnormalities from surface ECGs; this method improves sensitivity and specificity of the current technique used to identify the presence of abnormal ion current kinetics in the myocardial cells namely a prolongation of the QT interval on the surface ECG signal. We described in this paper the method and preliminary results, revealing the superiority of our technique that may play a role in the future of drug-safety assessment
Sponsorship	IEEE EMB
Starting Page	4010
Ending Page	4015
File Size	396968
Page Count	6
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.260492
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Delay Rectifiers Electrocardiography Drugs Current measurement Sensitivity and specificity Kinetic theory Myocardium Heart rate interval Signal processing
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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