NDLI: Subthalamic Nucleus Deep Brain Stimulation: Accurate Axonal Threshold Prediction with Diffusion Tensor Based Electric Field Models

Content Provider	IEEE Xplore Digital Library
Author	Chaturvedi, A. Butson, C.R. Cooper, S.E. McIntyre, C.C.
Copyright Year	2006
Description	Author affiliation: Dept. of Biomed. Eng., Cleveland Clinic Found., OH (Chaturvedi, A.; Butson, C.R.)
Abstract	Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become the therapy of choice for medically intractable Parkinson's Disease. However, the physiological mechanisms responsible for the therapeutic effects of DBS remain unknown, and quantitative understanding of the interaction between the electric field generated by DBS and the underlying neural tissue is lacking. Recently our group has developed various computational techniques to study the neural response to DBS. The goal of this study was to incrementally incorporate increasing levels of complexity into our computer models of STN DBS and address activation of the corticospinal tract (CST). Our model system was customized to an STN DBS patient and CST thresholds were calculated with electric field models that ranged from an electrostatic, homogeneous, isotropic model to one that explicitly incorporated the capacitance of the electrode-tissue interface, tissue encapsulation of the electrode, and diffusion-tensor based 3D tissue anisotropy and inhomogeneity. The model predictions were compared to clinical CST thresholds defined from electromyographic recordings from eight muscle groups in the arm and leg of the STN DBS patient. Coupled evaluation of the model and clinical data showed that accurate prediction of axonal thresholds required our most detailed model. In addition, the simplifications and assumptions typically utilized in neurostimulation models substantially overestimate neural activation
Sponsorship	IEEE EMB
Starting Page	1240
Ending Page	1243
File Size	528109
Page Count	4
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.260502
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Brain stimulation Tensile stress Brain modeling Predictive models Satellite broadcasting Medical treatment Parkinson's disease Electrostatics Capacitance Encapsulation
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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