NDLI: Modeling breast cell cycle regulation - overcoming drug resistance

Content Provider	IEEE Xplore Digital Library
Author	Arlt, D. Sahin, O. Korf, U. Loebke, C. Beissbarth, T. Hahne, F. Wiemann, S. Poustka, A.
Copyright Year	2006
Description	Author affiliation: Div. of Molecular Genome Anal., German Cancer Res. Center, Heidelberg (Arlt, D.; Sahin, O.; Korf, U.; Loebke, C.; Beissbarth, T.; Hahne, F.; Wiemann, S.; Poustka, A.)
Abstract	In breast cancer treatment for many cases intrinsic or acquired resistance against available therapeutics leads to death. According to the present biological understanding, drug resistance is caused by molecular mechanisms in the complex network of proteins that regulate cell proliferation by activation of the estrogen receptor (ER), hereby allowing the cell to bypass the classical estrogen receptor signalling pathway after inhibition of the ER. Target proteins for this study were chosen according to the present understanding of estrogen receptor based cell cycle control, including proteins from genomic and non genomic ER-dependant pathways, as well as from ER-independent signalling events. We used MCF7 cells (ATCC, HTB-22), to generate a Tamoxifen-resistant cell line out of this parental strain. The assay is based on upregulation of genes during Tamoxifen treatment, which allows the cells to proliferate in presence of Tamoxifen
Sponsorship	IEEE EMB
Starting Page	40
Ending Page	43
File Size	442238
Page Count	4
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.259761
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Immune system Proteins Cells (biology) Erbium Genomics Bioinformatics Biological system modeling Breast cancer Complex networks
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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