NDLI: Effects of LTP Induction on Hippocampal Cellular Excitability in the Freely Behaving Developing Rat Brain

Content Provider	IEEE Xplore Digital Library
Author	Blaise, J.H. Arnett, A.K.
Copyright Year	2006
Description	Author affiliation: Dept. of Eng. & Neurosci. Program, Trinity Coll., Hartford, CT (Blaise, J.H.; Arnett, A.K.)
Abstract	Our aim is to assess and quantify the exact effects of the induction of long term potentiation (LTP) on tonic inhibition and facilitation in a neural circuit within the hippocampal formation of neonatal rats. The neural circuit of interest in this paper is the perforant pathway-dentate gyrus synapse which serves as the first leg of the hippocampal trisynaptic circuit. A quantitative measure of the modulation of the perforant pathway/dentate gyrus circuit is the paired-pulse index which measures changes in the response of this circuit to a pair of pulses separated by varying interpulse intervals (IPI). It is known that such modulation influences the gating of neuronal transmission into and through the hippocampal formation; and, thereby, may play an important role in the development of learning and memory both in early life and throughout adulthood. Also important to this discussion is the finding that the dentate gyrus is one of the few areas of the rat brain which continues to generate new nerve cells well after birth. In an effort to quantify both age-related and LTP-dependent effects, LTP was induced using high frequency stimulation (HFS) of the perforant pathway-dentate gyrus synapse in freely behaving 10-12 day old, male Sprague-Dawley rats. Population spike amplitude measures which correspond to cellular discharge to a synaptic event were extracted from evoked field potentials recorded at the level of the molecular layer of the dentate granule cell population following induction of LTP in the same synapse. Preliminary results indicate the paired-pulse index was altered following induction of LTP
Sponsorship	IEEE EMB
Starting Page	4965
Ending Page	4966
File Size	194134
Page Count	2
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.260029
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Circuits Animals Pulse measurements Electrodes Pulse modulation Rats USA Councils Educational institutions Surgery Hippocampus
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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